Gurbuz District (, ) is situated in the southern part of Khost Province, Afghanistan. It borders Tani District to the west, Mando Zayi and Khost districts to the north and Pakistan to the east and south. The population is 23,200 (2006). The district center is the village of Sekhamir Kalay situated in the northwestern part of the district. It is inhabited by Gurbuz, a Wazir subtribe.