Interstate 464 (I-464) is an Interstate Highway in the U.S. state of Virginia. The highway runs from U.S. Route 17 (US 17) and Virginia State Route 168 (SR 168) in Chesapeake north to I-264 in Norfolk. I-464 connects two major highway junctions in the South Hampton Roads region. At its southern end, the Interstate meets two major highways that head toward North Carolina, US 17 and SR 168, and I-64, which follows the southern side of the Hampton Roads Beltway. At its northern terminus, I-464 has connections with Downtown Norfolk and Portsmouth via I-264.