Kwame or Kwamé is a Twi and Akan day name given to a boy born on a Saturday, originating in Ghana. People with this name include:

• Kwame Anthony Appiah, a Ghanaian-British philosopher of semantics and racism
• Kwame Brown, an basketball player in the NBA
• Kwamé Holland, an American rapper who enjoyed brief popularity during the golden age of hip hop; reemerged as a music producer named K1 Million
• Kwame Kilpatrick, former mayor of Detroit, Michigan
• Kwame Nkrumah (originally Francis Nwia Kofi Ngonloma), a Ghanaian politician (and for a time Life President) and one of the founders of Pan-Africanism
• Kwame Raoul, a Democratic member of the Illinois Senate, representing the 13th district since 2004
• Kwame Somburu (Paul Boutelle), an American socialist political activist
• Kwame Tucker, a Bermudian cricketer
• Kwame Ture (Stokely Carmichael), a Trinidadian-American black activist and leader of the Student Nonviolent Coordinating Committee and the Black Panther Party
• Osei Kwame Panyin, an 18th-century leader of the Ashanti Confederacy, located in what is today southern and central Ghana

Kwamé (born 1973) is an American rapper who enjoyed brief popularity in the late 1980s and early 1990s. He is currently a music producer, sometimes credited as K-1 Million or K1 Mil.