Margaret of Anjou (; 23 March 1430 – 25 August 1482) was the wife of King Henry VI of England. As such, she was Queen of England from 1445 to 1461 and again from 1470 to 1471. Born in the duchy of Lorraine into the House of Valois-Anjou, Margaret was the second eldest daughter of René of Anjou and Isabella, Duchess of Lorraine.