Merseburg-Querfurt was a district (Kreis) in the south of Saxony-Anhalt, Germany. Neighboring districts were (from northwest clockwise) Sangerhausen, Mansfelder Land, Saalkreis, the district-free city Halle, the districts Delitzsch and Leipziger Land in Saxony, the districts Weißenfels and Burgenlandkreis, and the Kyffhäuserkreis in Thuringia.