This article is about the former denomination. For individual churches of the same name, see Methodist Episcopal Church, South (disambiguation)

The Methodist Episcopal Church, South, or Methodist Episcopal Church South (MEC,S), was the Methodist denomination resulting from the 19th-century split over the issue of slavery in the Methodist Episcopal Church (MEC). Disagreement on this issue had been increasing in strength for decades between churches of the North and South; in 1844 it resulted in a schism at the General Conference of the MEC held in Louisville, Kentucky.