Mona Lisa Overdrive is a cyberpunk novel by William Gibson published in 1988 and the final novel of the Sprawl trilogy, following Neuromancer and Count Zero. It takes place eight years after the events of Count Zero and is set, as were its predecessors, in The Sprawl. The novel was nominated for the Nebula Award for Best Novel, the Hugo Award for Best Novel, and the Locus Award for Best Science Fiction Novel in 1989.

Mona Lisa Overdrive is the 13th album by Buck-Tick, released on February 13, 2003. The album is named after the 1989 novel Mona Lisa Overdrive by William Gibson. It reached number seven on the Oricon chart.