Moshenskoye was first mentioned in chronicles in 1545 as Nikolsky Pogost in Moshna. At the time, it belonged to the Bezhetskaya pyatina of the Grand Duchy of Moscow. One of the waterways between Novgorod and the basin of the Volga River run along the Msta and the Uver, and the foundation of Moshenskoye was presumably related to the existence of this waterway.