Classification of indigenous peoples of the Americas is based upon cultural regions, geography, and linguistics. Anthropologists have named various cultural regions, with fluid boundaries, that are generally agreed upon with some variation. These cultural regions are broadly based upon the locations of indigenous peoples of the Americas from early European and African contact beginning in the late 15th century. When indigenous peoples have been forcibly removed by nation-states, they retain their original geographic classification. Some groups span multiple cultural regions.

In the United States, an Indian tribe, Native American tribe, tribal nation or similar concept is any extant or historical clan, tribe, band, nation, or other group or community of Indigenous peoples in the United States. Modern forms of these entities are often associated with land or territory of an Indian reservation. "Federally recognized Indian tribe" is a legal term of art in United States Law with a specific meaning.