Route 49 is a state highway in the southern part of the U.S. state of New Jersey. It runs from an interchange with the Delaware Memorial Bridge extension of the New Jersey Turnpike (Interstate 295 and U.S. Route 40) in Deepwater, Salem County, where it continues north as U.S. Route 130 southeast to Route 50 and County Route 557 in Tuckahoe, Cape May County. The route serves Salem, Cumberland, Atlantic, and Cape May Counties, passing through rural areas and the communities of Salem, Bridgeton, and Millville along the way. It is a two-lane, undivided road for most of its length.