Route 53 is a state highway in Morris County in the U.S. state of New Jersey. It runs from  U.S. Route 202 in Morris Plains north to Bloomfield Avenue in Denville Township. The route, which is a two-lane undivided highway most of its length, intersects with Route 10, Interstate 80, and U.S. Route 46. For most of its length, the route runs a short distance to the east of New Jersey Transit's Morristown Line. It passes through industrial areas and wooded residential neighborhoods along its route.