Nezperce is a city in and the county seat of Lewis County, Idaho, United States. The population was 466 at the 2010 census, down from 523 in 2000. Nezperce is named for the local Nez Perce tribe of Native Americans. ("Nezperce" derives from a corruption of French words nez percé, literally "pierced nose.") There is one school district, Nezperce School District #302.