Pampanga River (also known as Rio Grande de Pampanga - Great River of Pampanga) is the second largest river in the island of Luzon, next to Cagayan River and the third largest but most important river in the Philippines. It is also the fourth longest river in the Philippines next to Agusan River and Mindanao River. It is located in the Central Luzon region and traverses the provinces of Pampanga, Bulacan, and Nueva Ecija.