In Greek mythology, Polydorus ( or ; , i.e. "many-gift[ed]") or Polydoros referred to several different people.

• An Argive, son of Hippomedon was called . Pausanias lists him as one of the Epigoni, who attacked Thebes in retaliation for the deaths of their fathers, the Seven Against Thebes, who died attempting the same thing.
• Prince Polydorus, son of the King Cadmus and goddess Harmonia, fathered Labdacus by his wife Nycteis.
• Prince Polydorus, a Trojan, was the King Priam's youngest son.
• Polydorus (son of Astyanax)   
• Polydorus of Sparta (reigned from c. 741 to c. 665 BC)

In art, Polydorus was:

• One of the three Rhodian sculptors who created the sculpture Laocoön and His Sons and signed the Sperlonga sculptures