PRP may refer to:

• People's Republic of Poland, former name of a country in Europe
• Pleasure Ridge Park, Louisville, in Kentucky, United States

PRNP (PRioN Protein) is the human gene encoding for the major prion protein PrP (for prion protein or protease-resistant protein), also known as CD230 (cluster of differentiation 230). Expression of the protein is most predominant in the nervous system but occurs in many other tissues throughout the body.