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Repressor lexA
Repressor LexA
or
LexA
is a transcriptional
repressor
that represses
SOS response
genes
coding primarily for error-prone
DNA polymerases
,
DNA repair
enzymes
and
cell division
inhibitors. LexA forms de facto a
two-component regulatory system
with
RecA
, which senses DNA damage at stalled replication forks, forming monofilaments and acquiring an active conformation capable of binding to LexA and causing LexA to cleave itself, in a process called
autoproteolysis
.
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