The "Siege of Antioch" may also refer to two battles in 1097 and 1098 during the First Crusade; see Siege of Antioch.

The Siege of Antioch occurred in 1268 when the Mamelukes under Baibars finally succeeded in capturing the city of Antioch. Prior to the siege, the Crusader Principality was oblivious to the loss of the city as demonstrated when Baibars sent negotiators to the leader of the former Crusader state and mocking his use of "Prince" in the title Prince of Antioch.