Sikeston is a city located both in southern
Scott County and northern
New Madrid County, in the U.S. state of
Missouri. It is situated just north of the "
Missouri Bootheel", although many locals consider Sikeston a part of it. By way of
Interstate 55,
Interstate 57, and
U.S. Route 60, Sikeston is close to the halfway point between
St. Louis, Missouri and
Memphis, Tennessee and three hours from
Nashville, Tennessee. The city is named after John Sikes, who founded it in 1860. It is the principal city of the Sikeston
Micropolitan Statistical Area, which consists of all of Scott County, and has a total population of 41,143.