U.S. Route 41 (US 41) in the U.S. state of Florida is a north–south United States Highway. It runs from Miami in South Florida northwest to the Georgia border north of the Lake City area. Within the state, US 41 is paralleled by Interstate 75 (I-75) all the way from Miami to Georgia (on the northern border), and I-75 has largely supplanted US 41 as a major highway.