U.S. Route 50 runs east–west across the southern part of the U.S. state of Ohio, passing through Cincinnati, Chillicothe, and Athens. It is mainly a two-lane road except for the easternmost part. Near Athens it becomes part of State Route 32, a four-lane divided highway known as Corridor D, and from Reedsville to the Ohio/West Virginia border it also overlaps State Route 7 before crossing into Parkersburg, West Virginia.