The Umatilla River is an tributary of the Columbia River in the U.S. state of Oregon. Draining a basin of , it enters the Columbia near the city of Umatilla in the northeastern part of the state. In downstream order, beginning at the headwaters, major tributaries of the Umatilla River are the North Fork Umatilla River and the South Fork Umatilla River, then Meacham, McKay, Birch, and Butter creeks.