In modern times, Assistant Secretary of State is a title used for many executive positions in the United States Department of State. A set of six Assistant Secretaries reporting to the Under Secretary for Political Affairs manage diplomatic missions within their designated geographic regions, plus one Assistant Secretary dealing with international organizations, and another dealing with working with other countries on narcotics issues. Assistant Secretaries usually manage individual bureaus of the Department of State. When the manager of a bureau or another agency holds a title other than Assistant Secretary, such as "Director," it can be said to be of "Assistant Secretary equivalent rank."