"What's Up?" is a song by American rock group 4 Non Blondes from their 1992 debut album, Bigger, Better, Faster, More!. It was released as the album's second single in 1993. It was very successful in Brazil and in several European countries, peaking at number one in Austria, Belgium, Germany, Ireland, the Netherlands, Norway, Poland, Sweden and Switzerland.

"'What Up?'" is a posthumous single by American rapper Pimp C, featuring rapper Drake and former-fellow UGK member Bun B. It's the lead single from Pimp C's first posthumous studio album, and third studio album over all, The Naked Soul of Sweet Jones.