The Wicomico River is a tributary of the Chesapeake Bay on the eastern shore of Maryland. It drains an area of low marshlands and farming country in the middle Delmarva Peninsula. The name "Wicomico" derives from the words wicko mekee, meaning "a place where houses are built," apparently referring to an Indian town on the banks. The river is one of two in Maryland with this same name, along with the Wicomico River (a tributary of the Potomac River) in south central Maryland.