Colonel William "Bill" Stryker, M.D. is a fictional supervillain appearing in American comic books published by Marvel Comics. He is usually depicted as an enemy of the X-Men. The character has been portrayed by Brian Cox in X2, Danny Huston in X-Men Origins: Wolverine, and Josh Helman in . In 2009, William Stryker was named IGN's 70th Greatest Villain of All Time.