Zilupe Municipality is a municipality in the historical region of Latgale, and the Latgale Planning Region in Latvia. The municipality was formed in 2002 by merging Zalesje Parish and Zilupe. In 2009 it absorbed Lauderi Parish and Pasiene Parish, the administrative centre being Zilupe. Zilupe, Lauderi, Zalesje and Pasiene are among the towns and villages located in the municipality.