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Azurophilic granule
An
azurophil
is a cellular object readily
stainable
with a
Romanowsky stain
. In
white blood cells
and
hyperchromatin
, staining imparts a
burgundy
or
merlot
coloration.
Neutrophils
in particular are known for containing azurophils loaded with a wide variety of anti-microbial
defensins
that fuse with
phagocytic
vacuoles
. Azurophils may contain
myeloperoxidase
,
phospholipase A2
,
acid hydrolases
,
Elastase
,
defensins
, neutral
serine proteases
,
bactericidal/permeability-increasing protein
,
lysozyme
,
cathepsin G
,
proteinase 3
, and
proteoglycans
.
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