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Coenzyme A
Coenzyme A
(
CoA
,
CoASH
, or
HSCoA
) is a
coenzyme
, notable for its role in the synthesis and oxidation of
fatty acids
, and the oxidation of
pyruvate
in the
citric acid cycle
. All
genomes
sequenced to date encode enzymes that use coenzyme A as a substrate, and around 4% of cellular enzymes use it (or a
thioester
, such as
acetyl-CoA
) as a substrate. In humans, CoA biosynthesis requires
cysteine
,
pantothenate
, and
adenosine triphosphate
(ATP).
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