The Crime Syndicate are teams of fictional supervillains from one of DC Comics' parallel universes, who are the evil counterparts of the Justice League of America. The original team was specifically known as Crime Syndicate of America and is sometimes abbreviated as CSA. This first superpowered Crime Syndicate team appeared in Justice League of America (vol. 1) #29 in August 1964. The primary successive incarnation, known as the Crime Syndicate of Amerika (with the variant spelling of America), first appeared in the 2000 JLA: Earth 2 graphic novel.

The National Crime Syndicate was the name given by the press to a multi-ethnic American confederation of several crime organizations. Its origins are uncertain.