Kryptonite is a material from the Superman mythos, specifically the ore form of a radioactive element from Superman's home planet of Krypton. First mentioned in The Adventures of Superman radio show in June 1943, the material has been featured in a variety of forms and colors (each with its own effect) in DC Comics publications and other media, including feature films, television series, and novelty items such as toys and trading card sets.

Kryptonite! is a 2011 Italian comedy film directed by Ivan Cotroneo.