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Nicotinic antagonist
A
nicotinic antagonist
is a type of
anticholinergic
drug that inhibits the action of
acetylcholine
(ACh) at
nicotinic acetylcholine receptors
. These compounds are mainly used for peripheral muscle paralysis in surgery, the classical agent of this type being
tubocurarine
, but some centrally acting compounds such as
bupropion
,
mecamylamine
, and
18-methoxycoronaridine
block nicotinic acetylcholine receptors in the brain and have been proposed for treating
drug addiction
.
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