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Syndecan
Syndecans
are single
transmembrane
domain proteins that are thought to act as coreceptors, especially for
G protein-coupled receptors
. These core proteins carry three to five
heparan sulfate
and
chondroitin sulfate
chains, which allow for interaction with a large variety of ligands including
fibroblast growth factors
,
vascular endothelial growth factor
,
transforming growth factor
-beta,
fibronectin
and
antithrombin
-1. Interactions between fibronectin and some syndecans can be modulated by the
extracellular matrix
protein
tenascin C
.
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