The 5-HT₁ receptors are a subfamily w 2 of 5-HT receptors that bind the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). The 5-HT₁ subfamily consists of five G protein-coupled receptors (GPCRs) that are coupled to G_i/G_o and mediate inhibitory neurotransmission, including 5-HT_1A, 5-HT_1B, 5-HT_1D, 5-HT_1E, and 5-HT_1F. There is no 5-HT_1C receptor, as it was reclassified as the 5-HT_2C receptor. For more information, please see the respective main articles of the individual subtypes:

• 5-HT₂ receptor
• 5-HT₃ receptor
• 5-HT₄ receptor
• 5-HT₅ receptor
• 5-HT₆ receptor
• 5-HT₇ receptor