Armenian Mesopotamia was a region in Northern Mesopotamia that was inhabited partly by Armenians, Tigranes the Great seized Northern Mesopotamia, and from 401 BC, to 387 AD was part of Kingdom of Armenia. Later it became part of Sassanid Empire, Arab Caliphate, Buyids, County of Edessa, Timurids, Kara Koyunlu, Ak Koyunlu, and the Safavids. Then, following the 1639 Treaty of Zuhab, it became part of the Ottoman Empire (although briefly taken by Nader Shah of the Iranian Afsharid dynasty) and Turkey. Armenian population remained until 1915's Armenian Genocide.