Nicopolis ad Istrum or Nicopolis ad Iatrum was a Roman and Early Byzantine town founded by Emperor Trajan around 101–106, at the junction of the Iatrus (Yantra) and the Rositsa rivers, in memory of his victory over the Dacians. Its ruins are located at the village of Nikyup, 20 km north of Veliko Tarnovo in northern Bulgaria. The town reached its floruit during the reigns of Trajan, Hadrian, the Antonines and the Severan dynasty.