The Jesus Lizard was an American rock band formed in 1987 in Austin, Texas and based in Chicago, Illinois. They were "a leading noise rock band in the American independent underground…[who] turned out a series of independent records filled with scathing, disembowelling, guitar-driven pseudo-industrial noise, all of which received positive reviews in underground music publications and heavy college-radio play."

Jesus Lizard may refer to:

• Jesus Lizard, a common name for the basilisk lizard genus, known for being able to run across water
• The Jesus Lizard, an American rock band formed in 1987 in Austin, Texas, and later based in Chicago, Illinois
• "The Jesus Lizard", a song on the Showbread album Age Of Reptiles
• Jesus Christ lizard