In mathematical logic, predicate logic is the generic term for symbolic formal systems like first-order logic, second-order logic, many-sorted logic, or infinitary logic. This formal system is distinguished from other systems in that its formulae contain variables which can be quantified. Two common quantifiers are the existential ∃ ("there exists") and universal ∀ ("for all") quantifiers. The variables could be elements in the universe under discussion, or perhaps relations or functions over that universe. For instance, an existential quantifier over a function symbol would be interpreted as modifier "there is a function". The foundations of predicate logic were developed independently by Gottlob Frege and Charles Sanders Peirce.

In mathematics, a predicate is commonly understood to be a Boolean-valued function P: X→ {true, false}, called the predicate on X. However, predicates have many different uses and interpretations in mathematics and logic, and their precise definition, meaning and use will vary from theory to theory. So, for example, when a theory defines the concept of a relation, then a predicate is simply the characteristic function or the indicator function of a relation. However, not all theories have relations, or are founded on set theory, and so one must be careful with the proper definition and semantic interpretation of a predicate.