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Additional
GABAA
English Wikipedia - The Free Encyclopedia
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GABAA receptor
The
GABA
A
receptor
(
GABA
A
R
) is an
ionotropic receptor
and
ligand-gated
ion channel
. Its
endogenous
ligand
is
γ-aminobutyric acid
(GABA), the major inhibitory
neurotransmitter
in the
central nervous system
. Upon activation, the GABA
A
receptor selectively conducts
Cl
−
through its
pore
, resulting in
hyperpolarization
of the
neuron
. This causes an inhibitory effect on
neurotransmission
by diminishing the chance of a successful
action potential
occurring. The
reversal potential
of the GABA
A
-mediated IPSP in normal solution is −70 mV, contrasting the
GABA
B
IPSP.
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