The
lineage markers are characteristic molecules for
cell lineages, e.g.
cell surface markers,
mRNAs, or internal
proteins. Certain antibodies can be used to detect or purify cells with these markers by binding to their surface antigens. A standard cocktail of
antibodies can be designed to remove or purify mature
hematopoietic cells or to detect
Cluster of differentiation from a sample. Those antibodies are e.g. targeted to
CD2,
CD3,
CD4,
CD5,
CD8,
NK1.1,
B220, TER-119, and Gr-1 in mice and CD3 (T lymphocytes),
CD14 (Monocytes),
CD16 (NK cells, granulocytes),
CD19 (B lymphocytes),
CD20 (B lymphocytes), and
CD56 (NK cells) in humans.