Mitochondrial fusion

Mitochondrial fusion is a process mediated by several large GTPases whose combined effects lead to the dynamic mitochondrial networks seen in many cell types. Mitochondria are dynamic organelles with the ability to fuse (fusion) and divide (fission), forming constantly changing tubular networks in most eukaryotic cells. The regulation of mitochondrial dynamics is crucial for the health of the cell. Defects in these dynamics are directly associated with numerous genetic disorders. Through mitochondrial fusion, these organelles can overcome the dangerous consequences of genetic malfunction. The process of mitochondrial fusion incorporates a variety of proteins, which assist the cell throughout the series of events that form this specific process.