In biology,
scaffold proteins are crucial regulators of many key
signaling pathways. Although scaffolds are not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into
complexes. In such pathways, they regulate signal transduction and help localize pathway components (organized in complexes) to specific areas of the cell such as the
plasma membrane, the
cytoplasm, the
nucleus, the
Golgi,
endosomes, and the
mitochondria.