Segezhsky District (; ) is an administrative district (raion), one of the fifteen in the Republic of Karelia, Russia. It is located in the east of the republic. The area of the district is . Its administrative center is the town of Segezha. As of the 2010 Census, the total population of the district was 41,215, with the population of Segezha accounting for 71.9% of that number.