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Additional
ADP-ribosylation
English Wikipedia - The Free Encyclopedia
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ADP-ribosylation
ADP-ribosylation
is the addition of one or more
ADP-ribose
moieties to a
protein
. It is a reversible
post-translational modification
that is involved in many cellular processes, including
cell signaling
,
DNA repair
,
gene regulation
and
apoptosis
. Improper ADP-ribosylation has been implicated in some forms of cancer. It is also the basis for the toxicity of bacterial compounds such as
cholera toxin
,
diphtheria toxin
, and others.
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