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Additional
CB2 receptor
English Wikipedia - The Free Encyclopedia
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Cannabinoid receptor type 2
The
cannabinoid receptor type 2
, abbreviated as
CB
2
, is a
G protein-coupled receptor
from the
cannabinoid receptor
family that in humans is encoded by the
CNR2
gene. It is closely related to the
cannabinoid receptor type 1
, which is largely responsible for the efficacy of endocannabinoid-mediated presynaptic-inhibition, the psychoactive properties of
tetrahydrocannabinol
, the active agent in
marijuana
, and other
phytocannabinoids
(natural cannabinoids). The principal endogenous ligand for the CB
2
receptor is
2-arachidonoylglycerol
(2-AG).
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