Debub Achefer or ("South Acheref") is one of the woredas in the Amhara Region of Ethiopia. It is named for the historic district of Achefer, which was first mentioned in the 16th century. Part of the Mirab Gojjam Zone, Achefer is bordered on the south and west by the Agew Awi Zone, on the north by Semien Achefer, and on the east by Mecha; the Lesser Abay River defines the woreda's eastern boundary. The administrative center is Durbete. Debub Achefer was part of former Achefer woreda.