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Muir-Torre syndrome
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Muir–Torre syndrome
Muir–Torre
syndrome
(MTS) is a rare hereditary,
autosomal dominant
cancer
syndrome that is thought to be a subtype of
HNPCC
. Individuals are prone to develop cancers of the colon, breast, and genitourinary tract, and skin lesions, such as
keratoacanthomas
and
sebaceous tumors
. The genes affected are
MLH1
,
MSH2
, and more recently, MSH6, and are involved in
DNA mismatch repair
.
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