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Additional
S-Adenosyl methionine
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S-Adenosyl methionine
S
-Adenosyl methionine
is a common cosubstrate involved in
methyl group
transfers, transsulfuration, and aminopropylation. Although these
anabolic
reactions occur throughout the body, most SAM is produced and consumed in the liver. More than 40 methyl transfers from SAM are known, to various substrates such as
nucleic acids
,
proteins
,
lipids
and
secondary metabolites
. It is made from
adenosine triphosphate
(ATP) and
methionine
by
methionine adenosyltransferase
(
EC 2.5.1.6]
. SAM was first discovered in
Italy
by
Giulio Cantoni
in 1952.
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