U.S. Route 53, or
U.S. Highway 53 (
U.S. 53), is a north–south
U.S. highway that runs for 403 miles (649 km) from
La Crosse, Wisconsin to
International Falls, Minnesota. It is the primary north–south route in northwestern Wisconsin, serving as a vital link between
I-94 at
Eau Claire, Wisconsin and the city of
Duluth, Minnesota. The entire route from Eau Claire to the city limits of
Superior, Wisconsin is a four lane
divided highway. The highway's northern terminus is at the
Fort Frances-International Falls Bridge in
International Falls, Minnesota, at the
U.S.-
Canadian border. Its southern terminus is in La Crosse, Wisconsin, at
U.S. Highway 14.