RAF proto-oncogene serine/threonine-protein kinase also known as
proto-oncogene c-RAF or simply
c-Raf or even
Raf-1 is an
enzyme that in humans is
encoded by the
RAF1 gene. The c-Raf protein is part of the
ERK1/2 pathway as a MAP kinase kinase kinase (MAP3K) that functions downstream of the
Ras subfamily of membrane associated GTPases. C-Raf is a member of the
Raf kinase family of
serine/threonine-specific protein kinases, from the TKL (Tyrosine-kinase-like) group of kinases.