Chronic granulomatous disease (
CGD) (also known as
Bridges–Good syndrome,
Chronic granulomatous disorder, and
Quie syndrome) is a diverse group of
hereditary diseases in which certain cells of the
immune system have difficulty forming the reactive
oxygen compounds (most importantly the
superoxide radical due to defective phagocyte
NADPH oxidase) used to kill certain ingested
pathogens. This leads to the formation of
granulomata in many organs. CGD affects about 1 in 200,000 people in the
United States, with about 20 new cases diagnosed each year.